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生物通
6月
ATP合酶OSCP亚基二聚体解聚策略:为药物发现提供新型单体化工具
本研究针对ATP合酶关键亚基OSCP在溶液中易形成二聚体而阻碍药物研发的难题,通过整合NMR、SAXS和nMS技术首次阐明其二聚化机制,并设计b-CT肽特异性诱导单体化,为靶向OSCP的线粒体疾病治疗策略奠定结构基础。 中起关键作用。近年研究发现OSCP不仅是ATP合酶的 ...
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