This is a preview. Log in through your library . Abstract N⁶-methyladenosine (m⁶A) is the most abundant internal messenger RNA (mRNA) modification, contributing to the processing, stability, and ...

RNA—in the form of messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA)—transforms the genome coded by DNA into proteins that form the backbone of all cellular functions. However, ...

Researchers have discovered that a chemical modification to the synthetic messenger RNA used in therapeutics can cause the cell’s machinery to misread its instructions and result in unintended immune ...

Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA ...

Changing just one atom in a COVID-19 vaccine lipid redirects delivery from the liver to the spleen, improving tumor ...

Fig. 2 Examples of ionizable lipids, sterols, phospholipids, and PEG-lipids used in LNP formulations. Created with BioRender.com. Fig. 3 High-throughput screening of the 3-component ionizable ...

Researchers at the University of Chicago have developed a technology for identifying new cellular RNA targets of small nucleolar RNAs (snoRNAs), a common but overlooked group of guide RNA molecules ...

“Nearly 30 years after Karikó first began her research into modified mRNA, the COVID-19 pandemic brought mRNA vaccines to the center of the scientific world.” On October 2, the Nobel Assembly at ...

N4-Acetylation of cytidine (ac4C) is an mRNA modification that enhances cellular mRNA stability and translation. Most eukaryotic organisms catalyze ac4C using a homologue of human N-acetyltransferase ...

Creative Biolabs optimizes the mRNA drug development model by integrating sequence design, RNA-protein interaction ...